Immunoglobulin genes and stereotyped antigenic receptors in chronic lymphocytic leukemia and other lymphoproliferative diseases

Introduction. The mutational status of immunoglobulin heavy chain variable region genes (IGHV) is the most important prognostic factor in chronic lymphocytic leukemia (CLL). Furthermore, a significant narrowing IGHV gene repertoire found CLL and other lymphoproliferative diseases. Aim — to review publication data on diseases regarding their clinical significance. General information. Nucleotide sequence rearranged unique marker tumor clone. patients with unmutated have an extremely unfavorable disease outcome contrast mutated genes. Patients benefit from conventional immunochemotherapy, while non-mutated require therapy escalation new targeted drugs. study stereotyped antigen receptors makes possible identify additional groups specific genetic features. Stereotype are also detected diseases, but significance has not yet been defined. However, be disease-specific.